If you’ve heard about people putting salmon sperm on their faces, your ears are not deceiving you. PDRN is the latest buzzy skin care ingredient, and yes, it’s commonly harvested from salmon DNA. So, what’s all the fuss about? Studies have shown its powerful potential to slow down signs of skin aging.
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In this article: REJURAN Turnover Ampoule (c-PDRN), VT COSMETICS PDRN 100 Essence and Medicube Jelly Gel Mask with Salmon DNA PDRN Pink Collagen
PDRN, or polydeoxyribonucleotide, is an ingredient made from DNA fragments that are typically extracted from salmon sperm, though some brands now offer plant-based or lab-created vegan versions. It has long been a staple in Korean skin care, but it’s now more popular than ever. PDRN has drawn attention for its ability to help boost elasticity, soothe irritation and reinforce the skin barrier without the use of aggressive actives.
Research suggests PDRN “can potentially improve skin quality, slow down aging, and improve dermal regeneration,” though further studies are needed to fully understand the breadth of its benefits. PDRN was also shown to support collagen synthesis, accelerate tissue repair, and have anti-inflammatory properties. Its ability to promote cell turnover and strengthen the skin’s barrier can contribute to a plumper, more resilient complexion.
Dr. Reju-All Advanced PDRN Rejuvenating Cream
Formulated with 99% pure salmon DNA, hyaluronic acid and niacinamide, this gel cream has earned rave reviews from BestReviews Executive Editor Maria Guido: “It goes on with a thick, luxurious feel, but absorbs quickly, leaving your skin feeling immediately more hydrated and supple.”
Medicube PDRN Pink Collagen Glow Jelly Serum
“I’ve been using this serum in conjunction with the Medicube Age-R Booster Pro, and my pores are visibly refined after just a few weeks of daily use,” says Guido.
REJURAN Turnover Ampoule (c-PDRN)
Formulated with salmon-derived PDRN, this product is designed to support skin regeneration. It targets uneven tone, rough texture and early signs of aging, while also delivering lasting hydration and barrier support.
For those who prefer a vegan product, this plant-based PDRN serum features an impressive 100,000 ppm concentration of PHYTO PDRN extracted from wild ginseng.
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“The skin under my eyes feels immediately hydrated,” says Guido of using these de-puffing undereye patches. “They’re also super delicate and feel amazing while I wear them.”
Medicube Jelly Gel Mask with Salmon DNA PDRN Pink Collagen
In the past month alone, 40,000 Amazon shoppers have snagged these plumping and firming sheet masks enriched with collagen.
Medicube Capsule Cream with Salmon DNA PDRN Pink Collagen
Tiny capsules help preserve the full firming and hydrating effects of PDRN. Once applied, they melt seamlessly into the skin.
Innisfree Green Tea Retinol PDRN Firming Serum
Combining 56% green tea PDRN with 1% retinol, this lightweight serum refines skin texture, firms the skin and smooths the appearance of fine lines.
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